An experimental space voyage goes awry, fusing astronaut Joe Neumann to his Sloppy-Joe sandwich. Returning to Earth, he slowly transforms into a blob of meat that grows larger and larger as he eats everyone it encounters: teenage lovers, lonely farmers, rock n' rollers, kids, dogs, even an entire Army platoon. Within days, he'll eat all of Cincinnati. Within weeks, the entire world! The daring mission leader, his scientific expert, and a blowhard military man lead the charge in fighting back, doing whatever they can to stop Joe and save the Queen City.